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A Study On The Relationship Between Radiologic Classification And Glycosaminoglycan Analyses of cystic Fluids In Oral Region

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Abstract

³¶ÀÇ ¼ºÀå¿¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â °ÍÀº ³¶¾×ÀÇ »ïÅõ¾ÐÀ̸ç, ¿©±â¿¡ Áß¿äÇÑ ¿µÇâÀ» ¹ÌÄ¡´Â
°ÍÀÌ ³¶¾×ÀÇ glycosaminoglycan ¼ººÐÀÌ´Ù. Àü±â ¿µµ¿¿¡ ÀÇÇÑ glycosaminoglycan ¼ººÐÀ» ºÐ
¼®ÇÏ¿© ³¶ÀÇ ¹æ»ç¼±ÇÐÀû ºÐ·ù¿ÍÀÇ ¿¬°ü¼ºÀ» ¾Ë¾Æº¸°íÀÚ ÇÏ¿´´Ù. ³¶¼º º´¼Ò 37¿¹ Áß Ä¡±Ù´Ü
³¶ 8¿¹, ÇÔÄ¡¼º³¶ 10¿¹, ¿ø½Ã¼º³¶ 10¿¹, ÀÜ·ù³¶ 2¿¹, ºñ±¸°³³¶ 3¿¹, ¼úÈļº»ó¾Ç³¶ 2¿¹, »ó¾Çµ¿
Á¡¾×·ùÁ¾ 1¿¹, ´Ü¹æ¼º¹ý¶û¸ð¼¼Æ÷Á¾ 1¿¹¸¦ ´ë»óÀ¸·Î glycosaminoglycan ¼ººÐ ºÐ¼®°á°ú ´ÙÀ½
°ú °°Àº °á·ÐÀ» ¾ò¾ú´Ù.
1. ´Ü°èÀû ÆǺ°ºÐ¼®½Ã Ä¡¼º³¶Áø´Ü¸ðÇü¿¡¼­´Â low-mobility ¹°Áú, heparin, hyaluronic acid,
dermatan sulfate µîÀÇ º¯¼ö°¡ Æ÷ÇԵǾúÀ¸¸ç, ÀÌ ¸ðÇüÀÇ ¹Î°¨µµ(sensitivity)´Â 100%À̾ú°í
ƯÀ̵µ(specificity)´Â 85%À̾ú´Ù.
2. Ä¡±Ù´Ü³¶¿¡¼­º¸´Ù, ÇÔÄ¡¼º³¶¿¡¼­´Â heparin ¼ººÐ°ú chondroitin-4-sulfate ¼ººÐÀÌ, ¿ø½Ã
¼º³¶¿¡¼­´Â chondroitin-4-sulfate ¼ººÐÀÌ À¯ÀÇÇÏ°Ô ¸¹ÀÌ °ËÃâµÇ¾ú´Ù(p<0.05).
3. ÇÔÄ¡¼º³¶°ú ¿ø½Ã¼º³¶¿¡¼­´Â À¯ÀÇÇÑ Â÷À̸¦ º¸ÀÌÁö ¾Ê¾Ò´Ù(p>0.05).
4. »ó¾Çµ¿¿¡¼­ ±â¿øÇÑ ³¶¿¡¼­´Â Ư¡ÀûÀ¸·Î heparin ¼ººÐ°ú dermatan sulfate ¼ººÐÀÌ ¸Å¿ì
³ôÀº ³óµµ¸¦ º¸À̸ç, ¾à°£ÀÇ chondroitin-4-sulfate ¼ººÐÀÌ °ËÃâµÇ¾ú´Ù.
5. ´Ü¹æ¼º¹ú¶û¸ð¼¼Æ÷Á¾Àº ³ôÀº ³óµµÀÇ dermatan sulfate ¼ººÐ°ú ¾à°£ÀÇ chondroitin-
4-sulfate ¼ººÐÀÌ °ËÃâµÇ¾ú´Ù.
6. ³¶¾×ÀÇ »ö»óÀº Ä¡±Ù´Ü³¶ÀÇ °æ¿ì ³ë¶õ»ö °è¿­ 5¿¹, ºÓÀº»ö °è¿­ 2¿¹, ÇÔÄ¡¼º³¶ÀÇ °æ¿ì
³ë¶õ»ö°è¿­ 4¿¹, °¥»ö°è¿­ 6¿¹, ¿ø½Ã¼º³¶ÀÇ °æ¿ì ³ë¶õ»ö°è¿­ 6¿¹, °¥»ö°è¿­ 2¿¹, ºÓÀº»ö°è¿­
1¿¹, ȸ»ö 1¿¹À̾ú°í, ÀÜ·ù³¶ÀÇ °æ¿ì ³ë¶õ»ö°è¿­ 2¿¹, ºñ±¸°³³¶ÀÇ °æ¿ì ³ë¶õ»ö°è¿­ 1¿¹, °¥»ö
°è¿­ 1¿¹, ¿¬ÃÊ·Ï¿ìÀµºû 1¿¹, ¼úÈļº»ó¾Ç³¶ÀÇ °æ¿ì ³ë¶õ»ö°è¿­ 2¿¹, »ó¾Çµ¿Á¡¾×·ùÁ¾ÀÇ °æ¿ì
³ë¶õ»ö°è¿­ 1¿¹, ´Ü¹æ¼º¹ý¶û¸ð¼¼Æ÷Á¾ÀÇ °æ¿ì ³ë¶õ»ö°è¿­ 1¿¹ À̾ú´Ù.
#ÃÊ·Ï#
This study was designed to evaluate the correlationship between radiologic
classifications of cysts in oral region and glycosaminoglycan analysis of cystic fluids
using cellulose acetate electrophoresis The materials for this study consisted of 37
cases-8 periapical cysts, 10 dentigerous cysts, 10 primordial cysts, 2 residual cysts,3
incisive canal cysts,2 post-operative maxillary cysts, 1 mucocele on maxillary sinus, & 1
unicystic ameloblastoma-diagnosed as cystic lesions radiologically.
The obtained results were as follows :
1. At the stepwise discriminant analysis, four variables-low mobility material, heparin,
hyaluronic acid, & dermatan sulfate-were used to define diagnostic model for the
odotogenic cyst The model produced a sensitivity of 100% and a specificity of 85% .
2. The intensities of heparin and chondroitin-4-sulfate were greater in dentigerous
cyst than periapical cyst(p<0.05)
The intensity of chondroitin-4-sulfate was greater in primordial cyst than in periapical
cyst(p<0.05).
3. It showed no statistically significant difference in glycosaminoglycan of the cystic
fluids between dentigerous cyst and primordial cyst(p>0.05).
4. On the fluids of the cysts originated %on maxillary sinus, there were especially
high intensities of heparin and dermatan sulfate, and low intensity of
chondroitin-4-sulfate.
5. On the fluids of unicystic ameloblastoma, there were high intensity of dermatan
sulfate and low intensity of chondroitin-4-sulfate.

Å°¿öµå

cyst radiologic classification; cyst fluid; glycosaminoglycan;

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